Intraoperative near-infrared fluorescence imaging of parathyroid adenomas with use of low-dose methylene blue.

Feasibility of portable gamma camera imaging in intraoperative radioguided parathyroid adenoma identification

Novel surgical applications include radioguided procedures in parathyroidectomy operations. In order to investigate the feasibility of usage of the portable gamma camera in parathyroidectomy operations; intraoperative radioguided parathyroidectomy operation was performed in three hyperparathyroidism patients with inconclusive preoperative parathyroid scintigraphy results. Intraoperative portabl...

Structure-Inherent Targeting of Near-Infrared Fluorophores for Image-Guided Surgery

Although various clinical imaging modalities have been developed to visualize internal body structures and detect abnormal tissues prior to surgical procedures, most medical imaging modalities do not provide disease-specific images in real-time. Optical imaging can provide the surgeon with real-time visualization of the surgical field for intraoperative image-guided surgery. Imaging in the near...

SPECT-CT fusion in the diagnosis of hyperparathyroidism

Objective(s): In this study, we aimed to analyze the relationship between the diagnostic ability of fused single photon emission computed tomography/computed tomography (SPECT/CT) images in localization of parathyroid lesions and the size of adenomas or hyperplastic glands. Methods: Five patients with primary hyperparathyroidism (PHPT) and 4 patients with secondary hyperparathyroidism (SHPT) we...

Turning on the lights: new technologies in optical diagnostics and therapeutics.

WHETHER coupling a light source to the first cystoscope or using a laser as a bladeless scalpel, a surgeon’s ability to harness light for surgical guidance and intervention is among the most important modern surgical innovations. In recent years optical diagnostics, particularly fluorescence imaging techniques, have emerged as a potentially important adjunct to standard white light endoscopic a...

Evaluation of Reflection Optical Imaging Characteristics Using Fluorescence with Near Infrared Wavelength at Different Depths of Tissue Equivalent Phantom